Endocrine Abstracts

Until 12th week of gestation foetus is entirely dependent on maternal thyroxine. Inadequate thyroxine replacement may lead to lower IQ of offspring and also an increased miscarriage rate.We audited 68 hypothyroid pregnant females to assess whether management of their thyroid status had met current standards. In the first trimester TSH is not an optimal monitoring marker as it is supressed by rising HCG level. According to established clinical guidelines ...

Background: Although the excision of ACTH-producing tumors or adrenal tumors is the principal treatment for Cushing syndrome (CS), pharmacologic treatment has a well-established role. Among various medical agents, ketoconazole (KTZ) has inhibitory effect over 17,20 desmolase, 17α-hydroxylase, 11β-hydroxylase, and 16α- and 18-hydroxylase; moreover, it also inhibits ACTH production and cellular growth, partly because of apoptosis induction.C...